Onun meşgul olduğu gerçeğine rağmen, o beni görmeye geldi.
- In spite of the fact that she was busy, she came to see me.
O, yorgun olduğu gerçeğine rağmen çalışmaya devam etti.
- In spite of the fact that he was tired, he continued working.
... of having accomplished in his life must be the fact that he ...
... spite of the fact that the question came into the light, ...